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-synuclein, which can be a major ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) stress, suggest that dysfunction in the intracellular proteinase techniques, including ubiquitin-proteasome process or lysosomal procedure, which eliminates unwanted toxic

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